SARS-CoV-2 lineage (501Y.V2) defining mutations in the spike receptor-binding domain (K417N, E484K and N501Y). The new variant is not related to England variant that have been discussed previously.
Emergence and rapid spread of a new severe acute respiratory syndrome-related coronavirus 2 (SARS-CoV-2) lineage with multiple spike mutations in South Africa | medRxiv
SARS-CoV-2 variant in the spike protein, (Mutations: deletion 69-70, deletion 144, N501Y, A570D, D614G, P681H, T716I, S982A, D1118H) (researchgate.net)
Up to date, the information about the severity of these new mutations is uncertain. Mostly the mutations have made in unfunctional sites. It could be considered in the vaccine development
Some of these mutations may affect the immunogenicity due to their localization in epitopic regions. While the RBD mutations may increase the interaction with ACE2 as early reported. Overall, which can impact on virus transmissibility and virulance.