In a recent review article titled “N1-methyl-pseudouridine (m1Ψ): Beneficial or Harmful for Cancer?” published in the International Journal of Biological Macromolecules, Rubio-Casillas, and colleagues discuss how mRNA vaccines may impact immunological pathways, potentially affecting cancer risk. Their research suggests that a high level of N1-methyl-pseudouridine (m1Ψ) in mRNA vaccines could promote cancer growth and metastasis in certain models. This raises concerns about the role of COVID-19 mRNA vaccines in cancer development. The authors recommend future clinical trials to explore lower levels of m1Ψ modification to avoid immune suppression. An earlier study by Professor Abdollah Jafarzadeh and team, published in the International Journal of Hematology-Oncology and Stem Cell Research, explores the potential link between SARS-CoV-2 infection and cancer. They found that cancer patients may have a higher susceptibility to COVID-19 due to their compromised immune systems from cancer treatments. Additionally, recovered COVID-19 patients may experience persistent immune abnormalities that could contribute to cancer development or recurrence. In my opinion, these studies highlight the complex interactions between COVID-19 and cancer, suggesting a need for further research to understand and address potential risks associated with the pandemic. I would be grateful if you could provide your insightful opinions on this matter. References: 1. Alberto Rubio-Casillas, David Cowley, Mikolaj Raszek, Vladimir N. Uversky, Elrashdy M. Redwan, Review: N1-methyl-pseudouridine (m1Ψ): Friend or foe of cancer?, International Journal of Biological Macromolecules, 2024. 2. Jafarzadeh A, Gosain R, Mortazavi SMJ, Nemati M, Jafarzadeh S, Ghaderi A. SARS-CoV-2 Infection: A Possible Risk Factor for Incidence and Recurrence of Cancers. Int J Hematol Oncol Stem Cell Res. 2022;16(2):117-27. doi: 10.18502/ijhoscr.v16i2.9205. PubMed PMID: 36304732. PubMed PMCID: PMC9547773. https://lnkd.in/e8uEbeB7 3. S. M. J. Mortazavi, S. A. Mortazavi, J. S. Welsh and L. Sihver, Journal of Biomedical Physics and Engineering 2023, DOI: 10.31661/jbpe.v0i0.2310-1679 https://lnkd.in/eQCW_MZQ
It is plausible. Recent research involving Peter Doshi and myself indicates the effectiveness and safety of the COVID-19 vaccines has been exaggerated in the clinical trials and later observational studies. So for me anything is on the table at this point. Summary here: https://okaythennews.substack.com/p/science-summary-covid-19-vaccines
Just for information Raphael Lataster is a major player in the anti-vax community.
My research indicating that "effectiveness and safety of the COVID-19 vaccines has been exaggerated in the clinical trials and later observational studies" wasn't enough? Thank you for your input...
Hmm, I feel a bit skeptical about this article. They advocate for mRNA vaccines that lack modified bases, however, they don't mention the CureVac COVID-19 vaccine that lacked modified bases and didn't perform well in clinical trials (below).
Article What went wrong with CureVac's mRNA vaccine?
Additionally, pseudouridine is the most abundant naturally occurring RNA modification (below). Why would a transient spike in pseudouridine have any impact on cancer? I think that it's prudent to approach any therapeutic with caution, but I am not convinced by the evidence that they present.Article Naturally occurring modified ribonucleosides
COVID-19 can have a direct impact on the immune system, and there is some evidence to suggest that it could potentially worsen outcomes for cancer patients or even increase the risk of developing cancer.
- Badges
- Science topic