Dear all,
we are working on dpp4 inhibitors to target AD. we would like to use sitagliptin as standard. Kindly let us know, on what basis we supposed to select the dose (for rats), as different researchers have used different doses like 10, 30, and 50 mg/kg.
If possible kindly provide me with proper calculation.
Rafael Franco
Irrespective on the compound the dose is usually less than 10 mg/Kg. Then I woulg suggest to use 10. If you get not results you may go to 20 but honestly doing to 50 and seeing "somehting" may be just unspecific. Is it possible to use big doses to "cure" disease, sure but better if one finds a compound efficacious at a low dose.
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