From the literature it was understood that 5HT3 agonist declines the memory and 5HT3 antagonists promotes cognition but i have seen the literature where it was mentioned that over expression of 5HT3A promotes / enhances the cognition.
how to correlate and understand this?
Hi Nehru Sai suresh Chalichem ,
5HT3A as an active form of the serotonin GPCR and a functional form of this ligand-gated ion channel uses K, Na and Ca ions to be activated and inactivated. Briefly, when serotonin as a ligand binds to this receptor, the channel opens or become activated and an excitatory response is being generated.
Depending on the region of the brain, this response may function in form of an enhancement of memory (in hippocampus for instance) or less possibly to attenuate cognitive function, though I have not seen such result.
If you use an agonist, it should actually enhance the activation of the receptor, unlike the antagonist (as in antiemetic drugs) that blocks the channel and deactivates its function.
My assumption (though it might not be completely correct) is: It is possible that after the peak and over saturation of the receptors, the affinity or sensitivity of the channel decreases and thus you may see such effect as a result. Such over blockade or over reuptake can be seen due to the changes in ion channels like Ca.
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