I`m formulating ranitidine hydrochloride dispersible tablets, regarding the extreme bitter taste of the API, the taste should be firstly masked before formulation. If wanted to use for e.g. beta-cyclodextrine, what is the recommended efficient taste masking technique?
Hi Alaa,
There are a variety of methods you can try to make drug/cyclodextrin inclusion complex. I have used a solution-based method (reference: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4370974/). Basically, you just need to mix the drug and CD in aqueous solution, equilibrate, and lyophilize the mixture prior to the following formulation. You can also try grinding and other methods, which you should be able to find in the literature easily. Hopefully, it helps. Let me know if you need more info or clarification.
Thanks,
Yangjie
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4370974/
A simpler technique is to granulate manitol or sorbitol with a dispersion of ranitidine plus beta cyclodextrin, dry by any method (fuidized bed drying of tray oven), mil the granulate and mix with flavors, fillers for chewable tablets (dextrates, copressible sugar) and lubricants. Or use the granulate in any application you wish. Best regards.
Maltodextrin and flavoring agents can be a handy option that can be used in blending, you can optimize the mixing time to provide an optimum sweetening affect and to avoid the bitter taste of the API.
A possible approach is the use of hot-melt extrusion which could allow an in situ inclusion complex formation.
- Badges
- Science topic
- Similar topics
- Clinical Pharmacology
- Dosing