Any sugessions that probiotics, prebiotics and protease resistant bacteriocins can be alternatives to antibiotics and can be used for eliminating antibiotic resistance?
You might check out this question which is related to your question:
https://www.researchgate.net/post/Can_probiotics_help_to_reduce_antibiotic_resistance
Yes but I does not see anything interesting there regarding any news related this topic.
Probiotics are basically supplements. perhaps we can say that it is an alternative of antibiotics as well.
Probiotic fermented foods and probiotic supplements products can enhance human health, it is an effective but not invasive treatment. It can be used as an important adjuvant factor for healthy nutrition or treatment of health disorders or diseases.
probiotics are effective and influence on health of human, but it dosn't mean they can be considered as antibiotics. there are some biopreservatives in food quality control, like l.plantarum and. l.rhamnosus and they produce some compounds that inhibit the fungus growth and compete with yeasts and molds on nutrients consumption,so prevent their growth. but not kill them.antibiotics can kill or slow the growth of bacteria, for example: mupirocin, clindomycin, ciprofloxacin and vancomycin are some kind of antibiotics
Thanks to all for reply if any news in this field please post here!
My focus is on restoring the gut ecology by optimising intestinal epithelial cell (IEC) function as a first priority - this includes benefit to the the secretion of endogenous anti-microbials like beta-defensin and others.
Then I ensure that I am providing appropriate prebiotics to encourage growth of commensals. I dont use probiotics as they typically dont colonise. However, they can provide symptomatic relief in a strain-specific manner.
@Christine, Best of Luck for your new research thoughts. I think it will work out.
Here is a story about an interesting new find of a bacteria in soil that has been used historically as a medicine. It might prove to be useful in place of some antibiotics: https://www.laboratoryequipment.com/news/2019/01/bacteria-found-ancient-irish-soil-halts-growth-superbugs?type=cta&et_cid=6567902&et_rid=272645636&linkid=Mobius_Link
Considering probiotics and / or prebiotics as alternatives or substitutes for antibiotics would be very compromising to affirm, since these do not act like antibiotics, the modes of action are very different. Although these ingredients provide certain benefits to human and animal health, to work properly depends on many factors, and its effects are medium and long term, while antibiotics have an immediate effect in the short term. Some probiotic strains produce certain proteins with antimicrobial effects, such as bacteriocins, among them, we have Nisin, which is used as a broad spectrum preservative in the food industry; Some consider Nisin as an antibiotic, but it would be necessary to carry out very rigorous clinical trials to consider it as such.
My goal is to minimise the use of antibiotics which it is generally acknowledged have been overused and abused. So, if I can encourage growth of commensals in the gut and beneficially influence the gut-immune interface, there will be some clinical situations in which antibiotics will not be needed at all. I need prebiotics to do this.
I have been developing probiotics and antimicrobial peptides since 2011. The field is still growing, the limitation is the lack of giant pharmaceutical funding to bring the technology from in vitro/ in vivo to clinical trial level.
With no hesitation, bacteriocins and other antimicrobial metabolites produced by bacteria are the future for developing safe antibiotic alternatives!
Antimicrobial peptides you mean peptides from non protein amino acids?
Hi Karen,
Some antimicrobial peptides have a natural amino acids, others undergo some chemical modifications including dehydration and methylation. This will create in-peptide non protein amino acids structures e.g. the lantibiotics family of bacteriocins.
Sure! With the recent data published in journals emerging alternatives such as probiotics, postbiotics and bacteriocins will definitely replace antibiotics. The mechanisms of their action is multiple and so pathogens wouldn't escape their action easily. Apart from antagonizing pathogens, they also help in improving the gut health of the host, immunomodulation and also production of beneficial enzymes and vitamins. These advantages out together are more than those of antibiotics
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