I always used applied biosystems synthesisers and they are excellent. They are also expensive and oligos are cheap if you negotiate a deal with any oligo manufacturer so your decision should be cost based. Expect to pay 15% for a service contract and see how many oligos you can get for this money bearing in mind companies are very quick in delivering large numbers of oligos but making your own is much slower. You vcan usually negotiate free delivery of oligos with the company.

When you do own a synthesiser you will find, like sequencers, that having one or a very small number of trained users will lead to much fewer service calls and problems than allowing wide access to the machine and much shorter down times and better usage of reagents

The trouble with home-made oligonucleotide synthesis is the high retail price and the short lifetime of phosphoramidite reagents, which means that the quality of syntheses decays rapidly unless you have a high turnover. This is why many labs switched to commercial suppliers (e.g. Sigma) decades ago. However, the situation may be different depending on the price and delivery time of commercial oligos in your country

I agree with both Pierre Béguin and Paul Rutland that it rarely makes sense for an institution to have its own synthesizer unless there is notable expertise and a high demand such that you never have to discard half used batches of reagents. By the time you factor in time for a technician, service contract, reagent cost etc, it usually only makes sense for large core labs. Your best bet is to find a commercial company that provides good service to your institution and negotiate a good pricing contract. If you do end up purchasing a machine, be sure the company provides repair service to your location.

Thank you Michael J. Benedik , Pierre Béguin and Paul Rutland . The point is we were used to order to MWG, Macrogen, ... but now because of the US sanctions! there are lots of problems regarding payments (almost impossible), and delivery time (some times more than 3 weeks!) and the price. Therefore we have decided to buy one for our institute and cover orders from all over the country to keep the machine running. This is the reason behind my question.

Dear Ali,

Be assured of all my (our ?) sympathy. Unfortunately, your hassles in getting commercial oligos are not the only suffering that the world owes to the current US president. My best wishes for getting a good machine and a reliable supply of reagents.

Pierre