Dear all,

I recently resolved a protein atomic structure by CryoEM. And intriguingly, the protein's structure shows similarity to a group of metatransferase (MTase) that on the PDB database, however, the when I looked purely sequence alignment to these MTase proteins, the conservation is pretty poor. I would like to know, whether there is an algorithm that can generate Phylogenetic metrics using structural alignment?

Many thanks!

Best,

Hong