We observed "naked nuclei" in metastatics cell complexes of lymth nodes after theirs PDT.
PDT induces apoptosis according to most of the publications:
Article The Role of Subcellular Localization in Initiation of Apopto...
Article Apoptosis during photodynamic therapy-induced ablation of RI...
Article Rapid Initiation of Apoptosis by Photodynamic Therapy
https://www.nature.com/articles/nrc1894
This article mentions necrosis as a result of PDT.
Those are cytoplasmic nucleoli as a result of apoptosis induction. A subset of these cells can survive by blebbishield emergency program. See my paper+Supplementary figures
Article Blebbishields, the Emergency Program for Cancer Stem Cells: ...
The following link answer the question
Nucleoli in large (giant) bi- and multinucleate cells after apoptosis-inducing photodynamic treatment
https://search.proquest.com/openview/54cc8941e8402fa4ab5c106d4c056cae/1?pq-origsite=gscholar&cbl=546307
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