Hi all. As we know Oxacillin antibiotic drug inhibits peptidoglycan synthesis in both gram-positive and gram-negative bacteria. Does anyone know which particular protein does Oxacillin binds to in order to inhibit the peptidoglycan synthesis in gram-positive bacteria, in particular of Methicillin-resistant Staphylococcus aureus strain? I am trying to do molecular docking of one of my compounds, as I speculate that the mechanisms of action of my compound inhibit the peptidoglycan synthesis process. Thanks in advance.
Airin Parvin Nipu But which penicillin binding protein? I have tried molecular docking on Penicillin binding protein 2A with Oxacillin, it did not binds to the active sites of the Penicillin binding protein 2A. Unless I interpreted the PBP-2A active site wrongly. By the way, any ideas about where the active site for PBP-2A, and whats the amino acid presents in it?
Oxacillin binds to Penicillin Binding Proteins 1-3. MRSA is resistant to oxacillin owing to the presence of mecA gene that encodes for PBP2a that has a very low affinity for beta-lactams like oxacillin. The following paper may provide the specific information that you require.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5458748/
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