Oral ketamin for cancer pain - experience?

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Will rat colon cancer cells (DHD/K12) derived from BDIX rats grow in Sprague Dawley ?

we plan to induce colon cancer by injection. Cell lines derive from BDIX rats, but our experimental setting would favour SD rats. any experience?

23 January 2021 1,437 2 View

How can I indicate to you that I am in fact the author of a book that you have informed me about for quoting other work of mine?

The question concerns this title: Viktor Smith Naming and Framing: Understanding the Power of Words across Disciplines, Domains, and Modalities. Routledge. All the best, Viktor

01 January 2021 4,197 1 View

Who has scheelite (CaWO4) activated by Eu, Sm, Tb, Er or other rare earths?

I would be grateful to my colleagues for the transfer of samples for the purpose of comparison with natural samples in terms of luminescent properties.

03 March 2020 6,099 1 View

Can anyone identify this plant?

This liana grows in the greenhouse of O.V. Fomin Botanical Garden of Taras Shevchenko National University of Kyiv (Ukraine). The plant has been introduced from Botanical Garden in Batumi...

29 January 2020 1,972 16 View

Compatible of QIAseq Stranded Total RNA Lib Kit and Ribominus Transcriptome Isolation Kit?

Dear all, I'm going to perform RNA-Seq with a QIAseq Stranded Total RNA Lib Kit and depletion with Ribominus Transcriptome Isolation Kit/ Ribominus concentration Kit. Does anyone have...

28 October 2019 8,120 1 View

Low bacterial RNA yeld with RNeasy MiniKit?

Dear all, I am trying to do an RNA extraction of different bacterial species with RNAeasy mini kit, protokol #4 (lysozyme lysis + proteinase K digestion). Unfortunately, I have a fairly low...

27 October 2019 5,537 0 View

What is a relation between relaxation time and mean free path for ideal gas?

These two values should be interconnected throufg integral of collisions. But I can not find a clear formula.

02 November 2018 3,613 1 View

Is there a database for bacterial protein mutants?

I'd like to screen on the sequences of available bacterial enzyme mutants (especially P. diminuta PTE enzyme [Uniprot ID: P0A434] ). Is there a database where I can find these mutants collected...

24 April 2018 6,471 2 View

Could you suggest some good algorithms for photo similarity recognition?

I would like to be able to compare photographs of places (mainly indoor) with existing database of photos to geo tag them. If you would be interested, this could lead to some research...

14 September 2017 9,947 3 View

I have L-histidine hydrochloride monohydrate. Help me, please, how can I eliminate HCl and water molecule to obtain L-histidine only?

Will NaOH or KOH neutralize L-histidine hydrochloride? And how can we separate products from each other if it will?

27 June 2017 6,690 4 View

Does Napabucasin soluble in dichloromethane and in ethanol?

I need to prepare a solution of Napabucasin (inhibitor of cancer cell stemness) in dichloromethane. The drug is expensive, so maybe somebody already tried to do it. If it is soluble, what is the...

02 March 2021 9,945 3 View

Could you please recommend some good journal that accept very long revie papers (approximately 6000+ words) in neurosurgery, cancer biology ?

01 March 2021 8,087 3 View

Which cell line should we use to perform biological dosimetry experiments?

We are preparing some experiments based on irradiating cells under different conditions in order to evaluate the effects in terms of DNA damage, genetic expression, etc. As our project is...

01 March 2021 3,355 3 View

Is CD44 degraded in lysosome together with hyaluronan after CD44 mediated endocytosis of hyaluronic acid?

Also when RHAMM binds hyaluronic acid, they get internalized, will RHAMM also be degraded? Or both CD44 and RHAMM will be transferred back to the cell membrane? Asking for breast cancer cell line...

01 March 2021 8,169 2 View

Experimental Design: How deal with pseudreplicates with immunological and clinical-chemical paramaeters?

Hello everybody, I am investigating the influence of a toxinon various clinical-chemical and haematological parameters in fish. I have three treatments (control, low dose, high dose) in my...

24 February 2021 1,243 1 View

Is it possible that Cancer cells could survive in heparinized blood for 48 hours?

Hi everyone, I am just wondering if we incubated 200 microliter of whole blood with 50 microliter of cancer cells(1bout 5000cells) do you think that cancer would survive for 48 hours?

23 February 2021 3,840 3 View

The PC12 cell line characteristics?

Hello dear scientists, Does the undifferentiated PC12 cell line in terms of chromosome characteristics, proliferation, and drug reactions have the characteristics of cancer cells? Where is it...

21 February 2021 8,945 3 View

What is the minimum number of exosomes/ml to have a good yield of total RNA for Illumina sequencing?

I am using IZON qEV2 columns to isolate exosomes from 100 ml of cancer cell conditioned medium. in NTA analysis I usually see concentration of 2x10^9 particles/ml. But when I proceed with this...

20 February 2021 6,879 3 View

Which way will be better to give OGT inhibitors doses through intravenous or orally for pregnant female rats and concentration suggestion?

I'm planning to use ST078925 OGT inhibitor from TimTec (OGT-O-linked N-acetylglucosamine (GlcNAc) transferase) for female rats.

16 February 2021 7,850 2 View

How to calculate the sample size required to detect the difference in pharmacokinetics of methotrexate?

I came across with this study here, https://www.clinexprheumatol.org/abstract.asp?a=5066 And this study says: "The sample size calculation was done to compare two different MTX starting dose...

14 February 2021 3,017 3 View

Maya Jane Bates

I think these people do

https://www.palliativedrugs.com/download/140114_Ketamine_for_pain.2013.FINAL.PIL.pdf

Boaz Samolsky Dekel

Dear Viktor,

Ketamine is hazardous . For high doses of opioids we use better Oral Methadone.

Jean Debetencourt

I have à new anesthésant with topical skin application without opioids

You need to sign secrecy agreement.

I do.not know if it works on terminal cancer...it works on arthritis and hematoms

The principal.ingredient is...water

Kind.regards

Jean db 0033608216307

This week I am in NY

Elizabeth Miller

Presume you have seen the following articles on oral ketamine which should help address your queries or you could contact the authorsArticle Oral Ketamine vs Placebo in Patients With Cancer-Related Neu...

and

https://www.jpsmjournal.com/article/S0885-3924(15)00272-9/fulltext

Leonardo Botelho

Here we use 15-25mg of oral Ketamine in this situation. When administered per oral Ketamine is metabolized by the liver to Nor-Ketamine which has less psychomimetics effects.