Migraine is strongly associated with impaired lifestyle. Instead, scientific society focused on its signs, symptoms, and the factors that are compensatory in essence. Therefore, success without lifestyle modification in the treatment of migraine is doomed to failure____?.
Is it possible?
I agree, lifestyle changes are important area for migraine management
Martin, B. R., & Seaman, D. R. (2015). dietary and Lifestyle Changes in the Treatment of a 23-year-old Female Patient With Migraine. Journal of chiropractic medicine, 14(3), 205-211.
Nazari, F., Safavi, M., & Mahmudi, M. (2010). Migraine and its relation with lifestyle in women. Pain Practice, 10(3), 228-234.
Dear Mohammad Zakir Hossain,
Thank you for the comments and also, references.
The indirect causes of migraines may indeed be related to and triggered by environmental stressors, emotional circumstances, lifestyle issues, etc.
Nonetheless, the ultimate etiology of migraines certainly appears to be, in one way or another, vascular in nature (i.e., related to blood vessels in the head). Triptans, which are 5-HT1b/d agonists appear to largely exert their action via cerebral vasoconstriction related to activation of these receptors. See:
Tepper SJ, Rapoport AM, Sheftell FD. Mechanisms of Action of the 5-HT1B/1D Receptor Agonists. Arch Neurol. 2002
Oxygen therapy for cluster headaches likewise appears to work by decreasing vessel dilation adjacent to the trigeminal nerve.
Thus, in my opinion, (and considering how truly awful chronic migraines are) their is an ethical danger in clinicians and researchers overemphasizing lifestyle, personal choices, etc., in migraine suffers, when these individuals are suffering from a vascular condition that they have no control over.
Dear Miky Timothy,
First of all, thank you for sharing your valuable knowledge with us.
Then, although, in terms of vasodilation, vasoconstriction and the action of triptans as "5-HT1b/d agonists", you are right, in my opinion, these vascular alterations are compensatory changes that are the consequence/s of circuit-related alterations in the brain system itself. We can consider the states such as CSD and the level of Oxidative Stress before vascular alterations in a migraine brain. Therefore, I think we have to seek the etiology and treatment of migraine from a neurodevelopmental perspective.
@Miky Timothy
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