Hello all,
I'm working in the field of infectious diseases and I'm using mice models of infection.
I saw a paper some times ago in which the authors using a scoring system in order to measure the general mouse shape.
They selected different parameters such as: fur, eye, general behavior, sociability, mobility.
I cannot find this publication back.
Have anybody got such a scoring system or a paper I can refer to?
Thanks in advance for your help.
two vital physical signs have been drooped out: ear size and tail length. You should include these too.
There are clinical scores used in influenza infection mouse model (0 = normal, 1 = slightly ruffled, 2 = ruffled fur, 3 = ruffled fur and inactive, 4 = hunched/moribund, and 5 = dead). Reference: Stout-Delgado HW, Vaughan SE, Shirali AC, Jaramillo RJ, Harrod KS. Impaired NLRP3 inflammasome function in elderly mice during influenza infection is rescued by treatment with nigericin. J Immunol. 2012 Mar 15;188(6):2815-24.
I hope this helps.