I'm carrying out study on BaP toxicity, looking for published article on in vivo study of BaP toxicity
Perhaps you could write the name of the chemical. There are many that use this abbreviations.
We just published an article about the effects of dietary fat on the uptake and distribution of benzo[a]pyrene and phenanthrene in atlantic salmon. We have shown that after a single oral dose cyp1a mRNA expression is up-regulated by BaP which is an aryl hydrocarbon recepter agonist. Furthermore, we have shown unextractable BaP-associated radioactivity from whole-body autoradiograms in several peripheral organs. This can be related to the production of benzo[a]pyrene-7,8-diol- 9,10-epoxide (BPDE) which is very reactive and can bind to cellular macromolecules such as proteins or DNA forming adducts that can lead to cellular damage.
De Gelder S, Bakke MJ, Vos J, Rasinger JD, Ingebrigtsen K, Grung M, Ruus A, Flik G, Klaren PHM & Berntssen MHG (2016). The effect of dietary lipid composition on the intestinal uptake and tissue distribution of benzo[a]pyrene and phenanthrene in Atlantic salmon (Salmo salar). Comparative Biochemistry and Physiology C 185-186:65-76
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