Can anyone suggest any reference for this statement?
There are approximately 1 x 104 physical particles of lentivirus for every pg of p24 antigen
I think that it just means that 10exp4 viruses will release an amount of p24 antigen into 1 ml of medium that measures as 1pg in the assay method used. The estimation method is given in the reference
Summers, M. F. et al. Nucleocapsid zinc fingers detected in retroviruses: EXAFS studies of intact viruses and the solution-state structure of the nucleocapsid protein from HIV-1. Protein Sci. 1, 563–574. https://doi.org/10.1002/pro.5560010502 (1992).
There are two references:
one from research paper: Briggs, J.A.G.; Simon, M.N.; Gross, I.; Kräusslich, H.G.; Fuller, S.D.; Vogt, V.M.; Johnson, M.C. The stoichiometry of Gag protein in HIV-1. Nat. Struct. Mol. Biol. 2004, 11, 672–675. [CrossRef] [PubMed]
second from the Merck product details: https://www.sigmaaldrich.com/IN/en/technical-documents/protocol/protein-biology/enzyme-activity-assays/lentiviral-titer-p24-assay
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