Hello colleagues. I am not a molecular biologist but am trying to understand the basis of HRD assays for breast and ovarian cancer. I am totally stumped by this LST data after studying it for hours. What are you talking about? is the distance between gene rearrangements or DNA breaks somehow related to BRCA deficient function? i.e. if the breaks are closer or further apart does either correlate with lack of homologous recombination?