Is there is any role of ivabradine in the management of HOCM in human? Any data or study available?

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James Kelly

It looks like there have been two studies on the role of ivabradine in HOCM in cats. These suggest its effect may be clinically significant, but inferior to atenolol.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4895467/

Studies on human subjects seem to be restricted to its use in coronary artery disease.

https://link.springer.com/article/10.1007%2Fs12325-010-0014-9

Biswajit Majumder

Thanks James for your answar. Beta blocker, verapamil and disopyramide are generally used to treat HOCM. Few studies are available to evaluate the role of ivabradine in HOCM in cat as you mentioned .I think human study is needed with this molecule where beta blocker are contraindicated like associated severe COPD.