I am trying to find evidence that CBT is useful for improving neuropsychiatric symptoms (such as depression, anxiety, agitation, mood, etc) in patients suffering from mild cognitive impairment or mild Alzheimer's Disease. I would be grateful if you could share individual studies or a review/meta-analysis meeting this criteria. Thank you.
You might want to read these papers, the first one is a recent trial and the remaining two are somewhat older meta-analyses:
Tonga, J. B., Benth, J. Š., Arnevik, E. A., Werheid, K., Korsnes, M. S., & Ulstein, I. D. (2021). Managing depressive symptoms in people with mild cognitive impairment and mild dementia with a multicomponent psychotherapy intervention: a randomized controlled trial. International Psychogeriatrics, 33(3), 217-231.
Orgeta, V., Qazi, A., Spector, A. E., & Orrell, M. (2014). Psychological treatments for depression and anxiety in dementia and mild cognitive impairment. Cochrane Database of Systematic Reviews, (1).
Orgeta, V., Qazi, A., Spector, A., & Orrell, M. (2015). Psychological treatments for depression and anxiety in dementia and mild cognitive impairment: systematic review and meta-analysis. British Journal of Psychiatry, 207(4), 293-298.
There are so many. Some, for example: JJG Galve "[PDF] Review of scientific evidence of cognitive-behavioral therapy" - Naturopathic Medicine, 2009 - dialnet.unirioja.es; Fernández-Álvarez, Héctor and Fernández-Álvarez, Javier. (2017) Integrative cognitive behavioral therapy. Journal of Psychopathology and Clinical Psychology 22 (2), 157-169; Bragança, Miguel; Palha, A .: Actas Espanolas de Psiquiatria. November / December 2011, vol. 39 Edition 6, p374-383 "Neurocognitive Disorders Associated with HIV Infection and Cognitive Behavioral Therapy"; "Effect of a cognitive-behavioral intervention on emotional variables in older adults", Daniela Contreras, Mónica Moreno, Pablo Esteban Livacic Rojas, Pablo E. Vera Villarroel, Patricia Araya, Natalia Martínez. Latin American Journal of Psychology, ISSN 0120-0534, Vol. 38, Nº. 1, 2006, pp. 45-58.
They are in Spanish and I think they are quite good from a scientific point of view.
Here’s a link to a Google scholar record of articles meeting your search criteria:
https://scholar.google.com/scholar?hl=en&as_sdt=0%2C36&q=cbt+alzheimer+meta+analysis&btnG=
It also appears there are many articles on CBT for caregivers of people with AD.
Hope this helps!
https://www.researchgate.net/post/Is_there_evidence_for_Cognitive_Behavioural_Therapy_being_effective_in_the_improvement_of_neuropsychiatric_symptoms_in_MCI_mild_AD_patients
Hello Rajiv,
That is an excellent question. CBT’s effectiveness on neuropsychiatric symptoms in MCI needs to be studied more as there doesn’t seem to very many RCTs on this topic.
But here is a systemaic review that could be helpful:
Carrion, C., Folkvord, F., Anastasiadou, D., & Aymerich, M. (2018). Cognitive therapy for dementia patients: a systematic review. Dementia and geriatric cognitive disorders, 46(1-2), 1-26. https://www.karger.com/Article/Fulltext/490851
If you’re interested in comparison with CBT’s effectiveness, we’ve written some articles on this topic:
Chiu, H. L., Chu, H., Tsai, J. C., Liu, D., Chen, Y. R., Yang, H. L., & Chou, K. R. (2017). The effect of cognitive-based training for the healthy older people: A meta-analysis of randomized controlled trials. PLoS One, 12(5), e0176742. https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0176742
Chiang, K. J., Tsai, J. C., Liu, D., Lin, C. H., Chiu, H. L., & Chou, K. R. (2017). Efficacy of cognitive-behavioral therapy in patients with bipolar disorder: A meta-analysis of randomized controlled trials. PloS one, 12(5), e0176849.
https://journals.plos.org/plosone/article/authors?id=10.1371/journal.pone.0176849
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