We developed an application for Mathematical and Computational Modelling of the Tumor Growth Based on Evolutionary Aspects of Hypoxia and Acidosis on the Microenvironment of Cancer Cells.
This application has the potential to be used in the study the growth pattern of the different cancer phenotypes, the clonal evolution of tumor, the tumor heterogenicity, Multi Drug Resistance and interactions of cancer cells and their microenvironment.You can find more details about the project in the link below.
I would like to ask, how we can label and define each cell is this kind of models to understand to know the origin of each cell, lifetime, and similar cells which create clones and generally how we can define clones in the mathematical models?
We applied a great idea to this question but I didn't find any similar approaches. Therefore, I will thankful if there is anyone who can help us to get more info.
It depends on the data structures used to define each cell. In the NEATG model, for example (https://peerj.com/articles/2176/) it is possible to track mutational events and lineage of each cell. This is useful for evaluating the growth of different clonal subpopulations.
https://peerj.com/articles/2176/
Hi Arash
Several references on attachment 1
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4265145/
4
https://www.google.com/url?sa=t&rct=j&q=&esrc=s&source=web&cd=5&cad=rja&uact=8&ved=0ahUKEwjHw4DX-rXWAhWmKJoKHdNtABgQFgg_MAQ&url=https%3A%2F%2Fgenomebiology.biomedcentral.com%2Farticles%2F10.1186%2Fs13059-016-0987-z&usg=AFQjCNFgtRR7jYRWfAfnASbV5RX8epcznQ
5
https://www.google.com/url?sa=t&rct=j&q=&esrc=s&source=web&cd=6&cad=rja&uact=8&ved=0ahUKEwjHw4DX-rXWAhWmKJoKHdNtABgQFghFMAU&url=http%3A%2F%2Fjournals.plos.org%2Fploscompbiol%2Farticle%3Fid%3D10.1371%2Fjournal.pcbi.1001132&usg=AFQjCNG_EYqXvttY6gjciRWMueS4GIN46Q
6
https://www.google.com/url?sa=t&rct=j&q=&esrc=s&source=web&cd=7&cad=rja&uact=8&ved=0ahUKEwjHw4DX-rXWAhWmKJoKHdNtABgQFghPMAY&url=http%3A%2F%2Fcancerres.aacrjournals.org%2Fcontent%2F77%2F14%2F3908&usg=AFQjCNH6q6SvcCwuvt9LZhBHQAALczrTPg
8
https://www.google.com/url?sa=t&rct=j&q=&esrc=s&source=web&cd=9&cad=rja&uact=8&ved=0ahUKEwjHw4DX-rXWAhWmKJoKHdNtABgQFghaMAg&url=http%3A%2F%2Fwww.editorialmanager.com%2Fviar%2Fdownload.aspx%3Fid%3D88415%26guid%3Da907b0ab-56fe-410f-bf55-456553a90742%26scheme%3D1&usg=AFQjCNEQijEQuNu1udmpeLjaYFxigyNGOQ
11
https://rsif.royalsocietypublishing.org/content/14/134/20170374.full.pdf
12
https://journal.frontiersin.org/article/10.3389/fonc.2013.00087/full
14
https://chemists.princeton.edu/torquato/files/publications/papers/jtb.pdf
15
https://chemists.princeton.edu/torquato/files/publications/papers/jtb.pdf
18
https://www.dmi.unict.it/~motta/reprints/Group_Papers/2011_FP_MMNP_to_appear.pdf
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