PGA solvents are toxic and I need a better approach to create films with this polymer.
In advance, Thank you for you time and consideration.
Arash Shams CO2 dispersion and plasticizers for reducing shrinkage in PGA films
- Liu, Z. (2008). Preparation of biodegradable polymeric scaffolds with porosity gradients and interconnected structures using a sub critical carbon dioxide foaming process (Doctoral dissertation, University of Ottawa (Canada)).
Можно попробовать экструзию при температуре темп-ра плавления 227–230 °С на хорошем двухвалковом экструдере.
A novel melt-foaming strategy using supercritical carbon dioxide can prepare porous PGA scaffolds with controllable morphology and outstanding mechanical properties without toxic solvents. Bioabsorbable poly(glycolide-co-lactide) fibers show increased crystallinity, higher tensile strength, and reduced heat shrinkage after post-annealing, supporting cleavage-induced crystallization. Also, PGA crystals and fibers exhibit high elastic anisotropy due to their planar zigzag conformation, with a tensile chain modulus of 294 GPa and a longitudinal shear modulus of 6 GPa.
Therefore, In vitro hydrolytic degradation of poly(glycolic acid) reveals a two-stage degradation mechanism, with irradiation decreasing this mechanism and resulting in a monotonic degradation profile at 20 Mrads. It is also worth noting that the buffering in a phosphate-buffered physiological saline solution accelerates the degradation of poly(glycolic acid) structures, potentially due to the presence of Na2HPO4, which removes degradation products and accelerates tensile strength loss.
Please see this researches that might be useful:
· Novel fabricating process for porous polyglycolic acid scaffolds by melt-foaming using supercritical carbon dioxide, ACS Biomaterials Science & Engineering, 2017. DOI: 10.1021/acsbiomaterials.7b00692
Best regards,
Dear Dr. Arash Shams,
You are quite welcome. It's my pleasure. I wish you all the best!!
Warm regards, Ali
Arash Shams You're very welcome! I'm glad I could contribute. If you have any more questions or need further assistance, please don't hesitate to ask.
Best regards
Alvena Shahid
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