Dear the haemoglobin genotype depends on the genes donated by each of the parents. There could be some drugs that suppress Haemoglobin S .

Thank you for your contribution Dr Obeagu, but here comes the quarry, is the suppression coming during meiosis or after? If post, it should be remembered that the chromosomes that carries S allele looks physiologically alike with the normal. Then....

The Best possible options: If both parents are carriers:

1. Although this suggestion is quite harsh but couple should avoid having any offsprings, as there is 25% chances of getting sickle cell disease.

2. If mother had conceived, then they should go for pre-natal testing to get to know genotype of baby and may decide to abort, if homozygous mutant.

I hope this information is helpful.

Thank you Dr. Amitabh, the information is helpful, but did not address, my question, 'Is there any scientific bases for couple with Sickle cell traits to believe that certain trado-medicine prevent them from having sickle cell child'?

I understood your question, my previous answer reflects the answer is 'no'. Sickle cell disease is a genetic disorder and there is no medicine or trado-medicine available which may prevent the disease to happen, if the child got homozygous mutation, the child will certainly bear the disease but severity may vary. There is 25% chance that child will inherit disease allele from both the parents.

Thank you Dr Amitabh, you are very correct, what some claim is that, 'the trado-medicine prevents the homozygous 'S,' from formation, and not the prevention of the disease development.

It is definitely impossible to prevent sickle cell disease by drugs. If both parents are carriers, there is a 1 in 4 chance of having an affected child.

Dr Stephan Lobitz, thank you. Do you think a research could be designed to look into the meiosis formation of the sex cells and look into exactly what makes the difference between the homozygous and hetero?

Dear Victor, this does not require any additional research. It is exactly known what is wrong. The carrier has one mutated gene, the patient has two. This has nothing to do with meiosis. Best. Stephan

Thank you Dr Stephan, but I did not absolutely agree with your position. Some Mutations can be reversed. Two, the mutation of sickle cell on chromosome 11 may have cause some physiological changes in the cell carrying the gene, which may cause their susceptibility to some reagents, chemical or drugs. This can therefore serve as a selection parameter.

Dear Victor,

I am sorry to say that, but this is not my position but state-of-the-art of science. This is basic knowledge of human genetics. However, I agree that gene therapy will soon be an option.

Stephan

Dr Stephan, you don't have to be sorry, we are all entitled to our opinion based on our experiences. And I guess, that is the benefit of a platform like this, experts, researchers, etc comes up with different ideas to solve problems. Thank you so much. I appreciate you sincerely.