Several million cholecystectomies are performed every year in the world.

On the other hand, a tiny group of people exist which lack the gallbladder from birth and which may serve for comparing and prognosing. Moreover, there are several species of mammals evolved that divorced with the gallbladder from the Pleistocene or earlier. Why and how do they live, forage, and do they have any physiological features that may be a reason for concern for us, human beings?

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