Is there any relationship between myokine & PI3K-AKT signalling to protect inflammation?

18 July 2017 1 3K Report

Proinflammatory cytokines are the major culprit to initiate immune response resulting in inflammation. And, exercise mediated myokines have special characteristics against pro-inflammatory cytokines such as TNF-alpha, IL-1, IL-6 etc. So, I want to know that, which pathways are involved that myokine stimulates and finally suppress the pro-inflammatory cytokines level? And, Is it possible for a myokine that protects inflammation via PI3K-AKT signaling pathway?

Divaker Choubey

The short answer is- Yes. see links below.

1. https://www.ncbi.nlm.nih.gov/pubmed/26107252

2. https://www.ncbi.nlm.nih.gov/pubmed/26838050

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