Is there any open-source software for creating receptor-based pharmacophore hypotheses in the absence of ligands and screening of ligand libraries?

15 November 2013 0 3K Report

I have a crystal structure of a protein without any knowledge of ligand and would like to create a receptor-based pharmacophore model for screening.

Badges
Science topic

More Naiem Issa's questions See All

How many journals can I submit my research to for publication? Can you recommend some high-quality, free journals in the field of ELT?

How many journals can I submit my research to for publication? Can you recommend some high-quality, free journals in the field of English Language Teaching (ELT)?

03 February 2024 9,165 6 View

What is the accurate and simplest method for detection bacterial siderophore?

Some researchers seek out an easy, cheap, and rapid technique to detect bacterial siderophore production; therefore, therefor how it can do it that???

28 January 2024 1,022 3 View

Determining the dataset: Paneldata or pooled cross sectional?

Hi everyone, i have a question regarding my dataset and would be grateful for any help: I have a dataset i downloaded online that gives me information about variables like Pool size, Dealvolume...

07 November 2023 1,005 5 View

I have to do TGA of the sample any body can help?

Required TGA results of the anode material for solid oxide fuel cell. If any body have the facilities of this characterization techniques, tell me if available.

05 September 2023 5,626 0 View

I am in need of Research paper on anode material for solid oxide fuel cell based on LSTF nay body can help me please?

The research paper should be of based on recent publication in high impact journal.

11 May 2023 737 0 View

Any one can send me JCPDS card no?

How to find the JCPDS card no. of any data?

03 May 2023 9,079 7 View

Why enzymes couldnot migrate from wells to stacking gel in electrophoresis? Is there is problem in its precipitation?

i have precipitated enzyme by acetone.. when i use coomassie staining in native gel electrophoresis, it couldnot migrate to stacking and then resolving gel. is there is a problem in acetone...

10 January 2023 2,353 5 View

Western Blot for Phospho eEF2?

Hello, I am getting lots of unspecific bands when I do western blot for the phospho eEF2, (when I do it for the total eEF2, i get only one clear band) can someone suggest a specific technique for...

03 November 2022 8,541 2 View

How do we remove carbon, copier, and another mineral from the Biosynthesis of Zinc oxide nanoparticles?

How do we remove carbon, copier, and another mineral from the Biosynthesis of Zinc oxide nanoparticles? (I have mixed the supernatant of bacteria with (20 mM ) of zinc sulfate for preparation of...

14 October 2022 3,815 1 View

Are is there a mathematical model for calculating the irradiance incident on PV panel?

I already have the GHI from the weather station are there any equations to calculate the GTI or only It can be accurately measured by a pyranometer installed at the same tilt angle as the PV panels ?

16 August 2022 5,875 2 View

How can I prepare virus for a TEM or SEM imaging?

I have virus (viral hemorrhagic septicemia virus) in suspension and the experiment will not involve cells. What level of TCID50 is preferred?

11 August 2024 3,115 1 View

Handling Missing Data and Building a Predictive Model with Incomplete Information ?

I am developing a predictive model for a water supply network that involves 20 influencing points. However, I only have historical data for 10 out of these 20 points. I would like to know how to...

10 August 2024 4,005 2 View

Is it possible to use the Fused Deposition Modeling (FDM) to additively manufacture interconnected porous structure generation of >100-200 micrometer?

Usually, additive manufacturing techniques like SEBM, SLS, and SLM are used for interconnected porous lattice structure generation with sizes of >100–200 micrometers. Can the Fused Deposition...

09 August 2024 7,892 0 View

How to define an anisotropic material with asymmetric elastic compliance/stiffness matrix in ANSYS APDL?

I need to model an anisotropic material in which the Poisson's ratio ν_12 ≠ ν_21 and so on. Therefore, the elastic compliance matrix wouldn't be a symmetric one. In ANSYS APDL, for TB,ANEL...

09 August 2024 5,048 2 View

GC-MS retention index prediticon?

Hello experts, Does anyone know any free software about retention index prediction ?

08 August 2024 7,403 2 View

How can I apply boundary conditions in an orthotropic steel deck numerical model using ABAQUS software?

I am trying to simulate vehicular loading on an orthotopic steel deck bridge section in ABAQUS software. The red arrow mark in the attached figure indicates the direction in which the vehicle will...

08 August 2024 719 0 View

What precautions should be taken while handling S. aureus enterotoxin Type B in the lab?

I would like to understand potential safety concerns while handling SEB in the lab. Especially while working in animal house facility. Would like to know precautions for handling. Sigma MSDS...

07 August 2024 6,034 3 View

Can you suggest reliable sources defining "3D mesh" and "3D city models"?

Dear fellow researchers, I am currently working on a paper where I need to provide a reliable reference that defines and distinguishes between 3D mesh models and 3D city models. Although I am...

06 August 2024 9,986 2 View

How to understand this crystallographic phenomenon of low temperature crystals in zeolite?

During low-temperature testing, new diffraction peaks that appear could be indicative of several phenomena. In one of our tests, we observed notable new peaks around 40° and 45° in a specific...

06 August 2024 726 3 View

Research Methodology - Impact of Corporate Reputation on Stakeholders Behaviors?

Please can anyone support with the survey questions based on RQ measures and propose how to do it in FMCG industry and include as well the role of brand equity Thanks

06 August 2024 949 0 View