Researchers have noted changes in cell structure in people with insulin resistance. However, I cannot find any literature where researchers are actually looking at the morphological changes taking place with insulin itself that changes its physiological ability to dock successfully with the cell’s insulin receptor.
Maybe a hint. There is a rat model for hypertension.
These rats tend to develop insulin resistance - because
certain proteases cleave insulin receptors and at the same
time CD18 which plays a role in immune reaction.
It was possible to inhibit these proteases with doxycycline.
After some weeks the insulin and CD18 receptors
were restored.
http://phys.org/news134030827.html
More links
http://www.augos.com/temp/Temp-Insulin-Resistance.html
Regards,
Joachim (not a medic)
Joachim, thank you for your input. But we are still looking at a structure [the insulin receptor] change and not looking at morphological changes with insulin itself. Looking for morphological changes with insulin is where no researchers have explored, so far.
Hypertension is one of the many concomitant problems that develop as the Insulin Resistance (RI) index rises.
We know that Advanced Glycation End products (AGE) bind to the Red Blood Cell that can then be measured in the serum analyte Hemoglobin A1C, that gives the clinician a mean fasting glucose for the last three month [the lifespan of a RBC]. Is insulin being glycinated, so the shape of insulin changes so it cannot dock with its receptor? We know that patients with “leaky gut” are very prone to RI. Are proteins binding to insulin [especially since insulin facilitates amino acid adsorption into the cell]? We know that IR has a strong inflammatory component. Are immune system cells attaching to insulin? All these are valid exploratory topics that can help unravel the obesity tsunami looming.
As for changes in the Insulin Receptor, there are six (6) basic sugars that are needed to unlock the receptor. See the work of Gilber N. Ling at http://www.gilbertling.org/
I do agree with you .
This question come to my mind and i think if we are able to see the effect of glucose on insulin molecule , and the effect of that on binding to it is receptor ?!
Such answer will help us to find a molecule that bind these sites and prevent insulin glycosilation and so will preserve it function and may be lower doses of the modified insulin is needed in diabetic patients