Most of the cancer cells are thought to have biotin receptor. However, I am unable to find any pancreatic cancer cell line having this receptor except a single paper stating PANK-1 as a biotin positive cell line. Please share your views on this issue.
Thank you
biotin could be favorably assimilated by tumor cells that over-express biotin-selective transporters. biotin can form stable complexes with avidin and its bacterial counterpart streptavidin. a biotin moiety is an attractive choice for live-cell imaging.
The cell line UN-KC-6141 was derived from a pancreatic tumor of a KrasG12D;Pdx1-Cre (KC) mouse at 50 weeks of age, whereas UN-KPC-960 and UN-KPC-961 cell lines were derived from pancreatic tumors of KrasG12D;Trp53R172H;Pdx1-Cre (KPC) mice at 17 weeks of age. The cancer mutations of these parent mice carried over to the daughter cell lines (i.e. KrasG12Dmutation was observed in all three cell lines while Trp53 mutation was observed only in KPC cell lines).
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0080580
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