Is there a way by which side effects of drugs can be reduced by altering the structure of a drug?

10 October 2015 0 3K Report

I want to work towards decreasing side effects of a particular class of drugs. Can anyone guide me as to how this can be done.

Badges
Science topic

More Nabeela Akbar Sayed's questions See All

What is difference between HypoGen and HipHop which are modules for generation of Pharmacophore models?

What is difference between HypoGen and HipHop which are modules for generation of Pharmacophore models? Which method should be used when. Advantages and disadvantages of each.

07 August 2015 8,734 0 View

What does a subgenomic replicon assay mean?

what does a subgenomic replicon assay mean? I came across this term in various papers but could not understand it. Can someone please explain its meaning in simple language.

07 August 2015 1,554 0 View

What does a truncated protein mean?

I have come across the term truncated N terminal various times in several papers. I want to know the importance of truncation and what it means. Why truncation is used.

07 August 2015 7,402 1 View

What does root mean square deviation(RMSD) mean. How is it useful wehile developing pharmacophore models and QSAR models?

07 August 2015 7,758 0 View

What does refinement mean in protein preparation?

There are various steps in protein preparation. One of them is refinement. Why is it required?

07 August 2015 9,614 0 View

What does asupramolecular interaction mean?

With respect to interaction between a ligand and a protein what does a supramolecular interaction mean?

07 August 2015 3,992 0 View

Convergence what does it mean in protein preparation?

In protein preparation why is restrained minimization in vacuum needed. What does convergence criteria for heavy atom RMSD mean. What is its importance. What happens if minimization is performed...

07 August 2015 525 0 View

What are tail anchored proteins?

what are tail anchored proteins

07 August 2015 1,347 0 View

What are the uses, advantages and disadvantages of Molecular dynamics simulations?

In molecular docking we can perform Molecular dynamics. What are the potential uses and how to interpret results in Molecular dynamics.

07 August 2015 5,942 1 View

What does a vector attribute mean and its importance in Phaermacophore modelling using PHASE provided by Schrodinger?

what does a vector attribute mean and its importance in Phaermacophore modelling using PHASE provided by Schrodinger?

07 August 2015 7,002 0 View

Is changing the medium during the experiment overestimate the results?

I am experimenting with cancer and non-cancer cells in a 12-well plate for 4 days with a seeding density 1*10^4/well, however, I noticed that the control group growth rate slows down on D3. Should...

07 August 2024 2,283 2 View

Which solvent is better to dissolve with secondary metabolites extracted from fungi?

I work on MCF7 cell cell for anticaner purpose and I wa to do drug preperation the drug ( secondary metabolites extracted from Aspergillus) My question which solvent is better with these secodary...

03 August 2024 4,725 2 View

Can i quantify a nanoparticle encapsulated in cell culture medium by hplc?

Hello, if you made a transwell assay where you incubate the cells with a nanoparticle-encapsulated drug and considering that in the oposite compartment you'll have both the free and encapsulte...

03 August 2024 2,730 1 View

What is the relationship between protein structure and N or C terminal tagging choosing?

I want to do 2,3-butanediol dehydrogenase(BDH) enzyme purification to confirm its activity for 2,3-butanediol. Before that, I need to confirm which N or C terminal tagging is better for enzyme...

28 July 2024 366 3 View

How to maintain the drug concentration in cell culture study for long term?

I am working in the filed of long acting drugs with Nano formulation. I want to study the efficacy of my formulation in 2D cell cultures while this required media change on every two days. In such...

24 July 2024 8,696 0 View

How to estimate a protien's size using Chimera or PyMol? how correct this estimated can be?

I need to know the approximate size of my target protein for Negative-stain EM. I have an alpha-fold predicted structure of the protein. I do not see any turtorial on internet for estimating the...

21 July 2024 5,732 3 View

How can I determine if a drug binds to a ribosome using a Cryo-EM map?

Hello, I am searching for the binding position of a drug in a ribosome, based on previous work indicating it binds there. The resolution of the ribosome-drug Cryo-EM map is around 2.5 Å. I've been...

19 July 2024 2,155 0 View

How to extract binding energy from pv.maegz file without using Schrodinger?

I have conducted virtual screening using Schrödinger on a database of 17,000 molecules. Unfortunately, I cannot use the system with the Schrödinger license at the moment. I am trying to find a way...

18 July 2024 2,881 4 View

How we can make this(as in figure) type of crystal structure (any software)?

I want to make this type of structure. Can anybody recommend the application for this?

15 July 2024 5,864 2 View

How to calculate percentage cumulative drug release?

How to calculate percentage cumulative drug release when, Total volume of dissolution media = 250ml Added formulation was equivalent to 10mg of drug Sample withdrawn = 1ml each time Sink condition...

15 July 2024 4,192 1 View