Is there a way by which side effects of drugs can be reduced by altering the structure of a drug?

10 October 2015 0 3K Report

I want to work towards decreasing side effects of a particular class of drugs. Can anyone guide me as to how this can be done.

Badges
Science topic

More Nabeela Akbar Sayed's questions See All

What does a subgenomic replicon assay mean?

what does a subgenomic replicon assay mean? I came across this term in various papers but could not understand it. Can someone please explain its meaning in simple language.

07 August 2015 1,484 0 View

What does a truncated protein mean?

I have come across the term truncated N terminal various times in several papers. I want to know the importance of truncation and what it means. Why truncation is used.

07 August 2015 7,170 1 View

What does root mean square deviation(RMSD) mean. How is it useful wehile developing pharmacophore models and QSAR models?

07 August 2015 7,657 0 View

What is difference between HypoGen and HipHop which are modules for generation of Pharmacophore models?

What is difference between HypoGen and HipHop which are modules for generation of Pharmacophore models? Which method should be used when. Advantages and disadvantages of each.

07 August 2015 8,630 0 View

Convergence what does it mean in protein preparation?

In protein preparation why is restrained minimization in vacuum needed. What does convergence criteria for heavy atom RMSD mean. What is its importance. What happens if minimization is performed...

07 August 2015 451 0 View

What are tail anchored proteins?

what are tail anchored proteins

07 August 2015 1,280 0 View

What are the uses, advantages and disadvantages of Molecular dynamics simulations?

In molecular docking we can perform Molecular dynamics. What are the potential uses and how to interpret results in Molecular dynamics.

07 August 2015 5,826 1 View

What does asupramolecular interaction mean?

With respect to interaction between a ligand and a protein what does a supramolecular interaction mean?

07 August 2015 3,924 0 View

What does refinement mean in protein preparation?

There are various steps in protein preparation. One of them is refinement. Why is it required?

07 August 2015 9,545 0 View

In protein preparation what does bond order mean. Why does it need to be corrected?

During protein preparation in Maestro by Schrodinger the bond order needs to be corrected. I want to know what bond order means, its importance and why it needs to be corrected

07 August 2015 7,101 0 View

Why Austenite grains in steel show much more twinning than ferrite grains?

It is oftentimes said to be a distinctive metallographic trait that differentiates a fully austenitic and a fully felly ferritic steel without etching that might distinguish between two. Why...

02 March 2021 728 2 View

What is the state of the drug inside solid lipid nanoparticles (SLNs)?

I am a little confuse with the mechanism of solid lipid nanoparticles (SLNs). The main point of encapsulating drugs into SLNs is because some drugs have low solubility in water. Therefore, SLNs...

01 March 2021 3,703 3 View

What is the most suitable server for predicting protein structures in bacteria?

I have used the i-Tasser several times, however it has been unavailable for several days. I tried the swiss-model, but the output was not very pleasant due to the model used. Is there any other...

28 February 2021 4,521 3 View

How does an antibody have full intact antibody + half antibody?

Hello, I was just wondering how does a antibody have full intact antibody + half antibody? Is it because of the drug conjugation?

28 February 2021 1,577 1 View

How do I choose contrasts in SPM8?

I am learning how to use SPM for PET and PET-MR analysis, but I haven't found any great resources that explain how contrasts work. I have a series of PET images where our hypothesis argues that...

24 February 2021 1,534 2 View

How to search for crystal structure for material with atomic position labelled?

I am using the crystallographic open database and materials project to search for cif file but the exact structure is not mentioned or how can I deduce that the given structure and atomic position...

23 February 2021 6,723 2 View

How to build fluid structure interaction simulation for elastic ring squeeze film damper in COMSOL?

22 February 2021 5,408 1 View

How to generate AA6061 alloy or any aluminium alloy crystal in material studio?

I need to carry out molecular dynamics simulation on Aluminium alloy. For this i need the crystal structure that which could be further replicated to form a structure.

22 February 2021 1,410 1 View

Does anyone have any ideas why drug-resistant malaria is increasing in Southeast Asia even when those drugs are no longer used?

When dealing with bacterial toxins, there are three varieties of microbes that develop in your petri dish: toxic, resistant, and susceptible. Initially, there are only toxic and vulnerable...

21 February 2021 6,084 5 View

Build an orthogonal box in ASE?

Hello, I was wondering the best way to build an orthogonal box filled with a defined crystal structure in ASE. I know it could be easily done in LAMMPS, but I guess it is also doable in ASE. The...

21 February 2021 5,899 4 View