I am searching for the base of diseases with unkown course. I want to understand the base of low grade inflammation and the molecules involved in it.
Nlrp3−/− mice exhibit defect in development of Th1 response(Gris et al. 2010) and NLRP3 seem to trigger a Th2 bias (Gurung et al. 2015; Daley et al. 2017). But my guess is this behaviour is tissue/cell dependent and so the jury is still out.
1. Daley, D., et al. (2017). "NLRP3 signaling drives macrophage-induced adaptive immune suppression in pancreatic carcinoma." J Exp Med 214(6): 1711-1724.
2. Gris, D., et al. (2010). "NLRP3 Plays a Critical Role in the Development of Experimental Autoimmune Encephalomyelitis by Mediating Th1 and Th17 Responses." The Journal of Immunology 185(2): 974-981.
3. Gurung, P., et al. (2015). "An NLRP3 inflammasome-triggered Th2-biased adaptive immune response promotes leishmaniasis." Journal of Clinical Investigation 125(3): 1329-1338.
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