Is there a clear link between MicroRNA and the diabetic nephropathy? and which MicroRNA specifically?

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Stefanie Malan

Yes, the miR-29 family is important. See article below:

Diabetes Complications: The MicroRNA Perspective by

Phillip Kantharidis1⇓,

Bo Wang1,

Rosemarie M. Carew1 and

Hui Yao Lan2

http://diabetes.diabetesjournals.org/content/60/7/1832.full

Maria Lucrecia Alvarez

Besides the miR-29 family, other microRNAs that are clearly involved in diabetic nephropathy include miR-192, miR-377, miR-216a, miR-217, miR-200, miR-21, etc.

These miRNA are responsible for many symptoms associated to diabetic nephropathy including proteinuria, increased extracellular matrix accumulation and fibrosis, etc. For a recent review on the subject see also Kato et al, MiRNA and the glomerulus. exp Cell res 2012. http://www.ncbi.nlm.nih.gov/pubmed/22421514

Geraldo A Passos

Apparently yes, the microRNAs are implicated in diabetes and nephropathy. I suggest the following reviews:

Lorenzen J et al (2012) MicroRNAs in diabetes and diabetes-associated complications. RNA Biol 9(6): (PubMed Epub ahead of print).

Kato M et al (2012) MicroRNAs and the glomerulus. mExp Cell Res 318: 993