Steroids are a most valuable adjunctive to the armamentarium available to health professionals for the management of mid and post endodontic
flare ups. Up to 80% of endodontic patients who report with preoperative pain continue to experience some level of pain following the endodontic
procedure. Since endodontic pain is often associated with chronic inflammation, the presence of bacterial by-products, influx of primed immune
cells and activation of the cytokine network and other inflammatory mediators, pain may be reduced by administration of glucocorticoid steroids.
During endodontic treatment and when managing trauma to the teeth steroids may be applied systemically (orally and/or parenterally) or locally
(i.e. intra-dentally via irrigants and medicaments).