In the 1980s, the above point served as the major reason for the development of centrilobular necrosis after administration of compounds which require metabolic activation. Centilobular localization of the P450s was demonstrated as an alternative to, say, alcohol dehydrogenase located in the periportal region. Does the current branch of biochemical toxicologists, while knowing about multiple molecular forms of hepatic CYP, follow those old dogmas?
Ilya B. Tsyrlov
Dear Alaaeldin,
I was talking about the current knowledge on exact distribution of distinct molecular forms of CYP within hepatic lobule
0 votes
0 thanks
- Badges
- Science method
More Ilya B. Tsyrlov's questions See All
Similar questions and discussions