Yes it is. The duraton of seizure varies with dose and animals.Seizure profiles are assessed through 30 minutes post-PTZ administration, evaluated every 10 minutes for signs such as immobility, abnormal limb splay, ataxia, straub tail, clonic/tonic seizures, muscle fasciculation, loss of righting reflex, and status epilepticus.
The following articles may help
1.Increased Seizure Latency and Decreased Severity of ...
https://www.hindawi.com/journals/ert/2013/532657/
2.Methods Find Exp Clin Pharmacol. 2009 Sep;31(7):423-32. doi: 10.1358/mf.2009.31.7.1393610. Effect of various antiepileptic drugs in a pentylenetetrazol-induced seizure model in mice. AkAdd your answerula KK1, Dhir A, Kulkarni SK.
3.Ann Neurosci. 2013 Jan; 20(1): 10–12.
doi: 10.5214/ans.0972.7531.200105 Reversal of experimentally induced seizure activity in mice by glibenclamide. Anand B. Pithadia, M. Pharm,1,* Archana Navale,1 Javed Mansuri,1 Rajesh S. Shetty,1 Shital Panchal,2 and Sunita Goswami3
We use 70 mg/kg, seizures develop in 1 or 2 minutes after i.p. injection and rapidly progress to stages 4-5 of Racine scale. Then mice become inhibited, and return to their normal motor activity in 10-20 min
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