I have my own opinion on this, but I am really interested in what the general concensus is by the field. Especially in the context of hESCs and hiPSCs, as we cannot perform the same tests as when utilising our mouse counterparts.
Hi Gareth, I cannot tell what is the general concensus, but I have my own opinion. the Zygote and the blastomeres are pluripotent due to mRNP particles in the ovoplasm. They originate in the maturing egg follicle with the contribution of the follicular cells.
The nascent messengers of the lampbrush chromosomes bind the nuclear HOX proteins and form the MORPHOGENS, which are responsible for the unlocking of new genes during emnbyogenesis. The iPSC cannot be comared with the original PCs, because thy do not contain morphogens in their cytoplasm.
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