Is mitochondria evenly distributed in leukemia cells? Do they have regular shape as for normal cells?

15 October 2020 1 7K Report

Currently, I am facing some issues related mitochondrial localized expression of my fluorescent protein. So, if someone have any idea about the above query, it would be wonderful.

Ugochi Chilaka

It depends on the type of leukemia involved. In myeloid leukemias, the cells are the same as normal, only that there is maturation arrest at a particular stage of development. They are also more in number than in normal individual. In ALL L3, subtype, which is the burkitt-like type of cell, there may be a difference in the mitochondrial arrangement since it's a bit far from the look of a normal cell.

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