I studied on the molecular mechanism and trigger of the sigma E-dependent cell lysis and programmed cell death (PCD) in Escherichia coli. The experiments revealed the lysis phenomenon of E. coli cells which have been found to be in the viable but non-culturable (VBNC) form. The relevant papers are appended below.

     However, now I am thinking whether this can be concluded as the programmed cell death (PCD) since the defective cells undergo lysis. Next, the “lyzed debris could be in use of the remaining cell population as nutrients”---is it possible? My current experiment is focusing on this. If anybody is conducting such research, please share some idea or advise.  

Masayuki Murata, Rashed Noor, Hiroshi Nagamitsu, Shuhei Tanaka, Mamoru Yamada. A novel pathway directed by sigma E for elimination of viable but non-culturable cells in Escherichia coli. Genes Cells 2012; 17: 234-247.

Rashed Noor, Masayuki Murata, Hiroshi Nagamitsu, Gracjana Klein, Satish Raina, Mamoru Yamada. Dissection of sigma E-dependent cell lysis in Escherichia coli: Roles of RpoE regulators RseA, RseB and periplasmic folding catalyst PpiD. Genes Cells 2009; 14(7): 885-899.

 

Rashed Noor, Masayuki Murata, Mamoru Yamada. Oxidative stress as a trigger for growth-phase specific sigma E-dependent cell lysis in Escherichia coli. J Mol Microbiol Biotechnol 2009; 17(4): 177-187.

 

Md. Shahinur Kabir, Daisuke Yamashita, Rashed Noor, Mamoru Yamada. Effect of sigma S on sigma E-directed cell lysis in Escherichia coli early stationary phase. J Mol Microbiol Biotechnol 2004; 8(3):189-194..

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