Yes, technically it is possible to do that but it may not be the best way.
The paid versions of the V4 have an open domain size, but the simulations will take much much longer on larger areas. It depends what you are looking for. Maybe it would be much faster (and easier) to use other CFD softwares on that scale.
The free version has a limited domain, i.e. 250*250 cells max. So if you want to cover a rather large area, your cell sizes will be huge. decreasing the accuracy.