Dear Dr Mclnerney , Thank yo so much for the paper. 

Yes. It is possible but very difficult. During our reaserach for our article on keloids, we came across some papers which have looked deeply into this question. here are the links

http://www.ncbi.nlm.nih.gov/pubmed/19065711

http://www.ncbi.nlm.nih.gov/pubmed/15990682

http://www.ncbi.nlm.nih.gov/pubmed/23222148

Hope this is useful. Thank you

Thank you Sreekar. Best regards.

It's very difficult.  Ramos,Gragnani & Ferreira  published a nice review of the problem in J Burn Care Res 2008; 29: 363-368 and included some advice for the would-be researcher:  Basically, if you've got lots of money and don't mind high animal mortality rates, then go for athymic mice with engrafted human hypertrophic/keloid tissue.  However, this is limited in it's usefulness, as the human tissue is obviously brought out of its natural environment, so there are difficulties about drawing conclusions that translate to human physiology or treatments.  If you can afford to set up a large animal experiment, go for red Duroc pigs, as these can develop hypertrophic-type scars, which have been shown to have similar biochemical profiles in many, but not all ways, to human hypertrophic scars.  Their size and handling difficulties also make interventions (drugs, surgery) difficult to follow and interpret.  If you can't afford any of the above, then the rabbit ear model has been used extensively in intervention research, although, you have to be careful about interpretation here also, since this model involves removing not only skin, but also perichondrium and therefore is partly dependent upon the role of these cells, in a way that human hypertrophic scarring is not.

Finally - as Dr McInerney has stated, these are hypertrophic scar models, not keloid models.  The best bet in order to have a result that would last over a long period of time, would be to use human subjects, with all the ethical and planning problems that entails.  Good Luck!