Usually, dopamine is electrochemically detected when used HPLC. This is particularly important if the amount expected is very low. Are you planning to test for dopamine levels in the medium or total content?
No, you will not have adequate detection -- you can do the calculations -- the absorptivity of dopamine in the UV is ~30 mM-1cm-1 in the UV so if you take the Beer-Lambert Law and plug in known amounts of DA in striatum, and estimate the minimal volume you can make your sample (i.e., highest concentration), you will find that you do not have any signal-to-noise. This is why in the pre-HPLC days, people did chemical conversion and fluorescent measurements of DA and NE to increase sensitivity, but this still was only a fraction of the sensitivity of HPLC.