Is it possible to conjugate DOTA with DOX (doxorubicine) and under which condition?

30 April 2014 1 8K Report

Bioconjugation of bifunctional chelate DOTA with DOX.

There is increasing interest in the bio-conjugation of peptides and antibody with bi functional chelating agent (DOTA, DTPA), used for RRNT and RIT.

Negri Roberto

It depends what functional group of DOX you want to use to make the bond... If the amino group is your choice, then you just need to use your DOX with any DOTA-like compound with a functional group that reacts with amines (DOTA-SA or DOTA with isothiocyanate mojety). You could find protocols for these reactions in the literature

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