What I am trying to say is, instead of immediately giving a response when the material exists in the environment, independed of the concentration, can we make the cell concentration sensitive?
For example, My cells start synthesising A protein when X exists in the environment. I want my cell to synthesise A when the concentraion of X is higher than 0,01 M and no response when the concentration is less then 0.01 M. Is it possible?? If yes, how?
Generally speaking, this is how it already works. Usually the binding of necessary transcription factors to promoter elements for the start of transcription is transient. But, the higher the inducer is in the environment, the more the transient interaction is triggered, so the stronger the observed induction.
You can test this empirically by doing a log dose response curve of your inducer. If you do so, you could find the absolute baseline of your induction response and call that your "threshold." Or, you could choose the low inflection on the s-curve.
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