The IVGTT Bergman minimal model is given by:

dG(t)/dt = - p1(G(t) - Gb) - XG + D

dX(t)/dt = - p2.X(t) + p3 (I(t) - Ib)

dI(t)/dt = - n(I(t) - Ib)

dD(t)/dt = - BD(t)

Q1/ For Type 1 diabetic patient, the parameter p1=0 is adopted in many control literature. Is it proper or we should take other values for p1 while simulation purpose?

Q2/ I have designed a fuzzy logic controller for Bergman minimal model with considering nominal values of parameter p1 and p1=0 both. Which parameter value will be appropriate for it?

Q3/ If I have to linearize this model,then what will be the justified operating points/values of states around which the linearization should be done?