I have a list of enzymes and KEGG orhthologous ids corresponding to the pathways of interest can I build a mathematical model for this data.
What are the resources available for this purpose.
Thank you for your inquiry, and thank you very much for your interest in my reports. However, I am sorry I could not reply your question because I am working at another company now. If you have interesting my studies, please ask questions to my coresponding auther,Kenji Imou.
If I understood your question correctly then my answer would be, yes you can build mathematical models for protein signaling pathways. Based on your model (stochastic vs. deterministic) you might need to collect some experimental data to fit the model into it. There are lot of literature available in this field of study. Our group has done mathematical modeling for several different pathways. You can look onto that to get preliminary idea.
Dear Rahman,
Nice to know your group is working on mathematical modeling of cell signaling pathways. Do you have any idea for Sonic hedgehog signaling mathematical model?
Hi Lakshmi,
Yes, it is possible to model them; each enzyme could be modelled as a binary string (as in genetic algorithms, and then for instance use a genetic algorithm combined with stochastic theory. I do not work in this field, but it is possible. The final method depends on your aim. Regards,
Petre Miu.
Thanks Dr Miu
I shall appreciate if you could suggest some tools or methods in this regard as I am very new to this dimension
Lakshmi,
In my published book last month, one can find the entire MATLAB code for a genetic algorithm I developed for a specific application.
you can use my email address: [email protected]
I'll give you a much more detailed answer.
Regards,
Petre Miu
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