See links:

Article Efficacy of coenzyme Q10 in patients with cardiac failure: A...

Article Coenzyme Q10 - A new player in the treatment of heart failure?

Article Effects of ubiquinone (coenzyme Q10) on myopathy in statin users

Article Considerations for Supplementing with Coenzyme Q10 During St...

Article Coenzyme Q10: The essential nutrient

Article Coenzyme Q10 Supplementation in Aging and Disease

Regards

Good question, however as for many supplements,, that are both elaborated by some organs and brought by the alimentation, is it worth the game ? There are some positive publications, but I remember the same kind of publications 20 years ago on Vitamine C and other stuffs, like carotene. Therapeutic use is rather limited (deficiency). Same fate ?

No, its not or should not be under rated one as supplement. However, it must be used after your medic's consultations.

i guess one of its indications to use is in patients having body aches after starting statins.

Regards

Dear Fazleh Mahomed

Further to what i said, here are few evidence based uses.

Indications of Co-Enzyme Q-10

1- Familial hypercholesterolemia with inherited Co-Enzyme Q-10 deficiency

Reference: Suárez-Rivero JM et al. Intracellular cholesterol accumulation and coenzyme Q10 deficiency in Familial Hypercholesterolemia. Biochim Biophys Acta Mol Basis Dis. 2018 Oct 4. pii: S0925-4439(18)30386-7. doi: 10.1016/j.bbadis.2018.10.009.

2- Co-Enzyme Q-10 and migraine prevention

Reference: Ennio Pucci et al. P032. Coenzyme Q-10 and migraine: a lovable relationship. The experience of a tertiary headache center. J Headache Pain. 2015; 16(Suppl 1): A139. doi: 10.1186/1129-2377-16-S1-A139.

So I feel these are some evidence which I found after my search and there could be more, but I believe its misuse is also very common.

I hope it helps.

Regards

I have a lot of anecdotal positive responses from patients.

Increase in energy, memory and more

Placebo effect?

Good question, in my practice it works as indicated.

By the way can someone really guide me how often they need to give Co-enzyme Q-10 to their hypercholestrolemia patients?

dear Fazleh Mahomed

Placebo effect is real possibility. That will require a real double blind placebo control trial and which is difficult to conduct.

I shared the evidence which was to some extent known to me as i was doing some research on statins and some i extracted from pubmed. i see some cardiologist suggesting this Coenzyme Q-10 if u are using statins and having body aches.

Regards

Hi Mohomed,, and Sikandar.. Co enz q have theoretically many attractive health benefits. However there is no large well designed trial to establish it. Meta-analysis of small six trials showed that it might have some benifit in reducing systolic blood pressure without any effect on diastolic pressure. It has probably no role in improving lipid parameter. Majority of systematic health benefits of it probably because of placebo effect. Following article might help you.. Thanks

Yes, a large well designed trial is available:

Article The Effect of Coenzyme Q10 on Morbidity and Mortality in Chr...

multicenter study with over 400 heart failure patients with +40% decrease in mortiality and +40% decrease in MACE vs placebo

Dear Srdjan Atanasijevic

Can CoQ10 be measured by routine laboratory techniques or you have any reference to link me with this.

It would be further interesting to know if this enzyme was sort of driver to all these metabolic HMGCoA reductase activity.

Regards

agree with@ Isaac Karimi

regards

Sikandar Hayat Khan : Peter Lambrechts article above may assist you with your queries

Regards

See links:

Article Efficacy of coenzyme Q10 in patients with cardiac failure: A...

Article Coenzyme Q10 - A new player in the treatment of heart failure?

Article Effects of ubiquinone (coenzyme Q10) on myopathy in statin users

Article Considerations for Supplementing with Coenzyme Q10 During St...

Article Coenzyme Q10: The essential nutrient

Article Coenzyme Q10 Supplementation in Aging and Disease

Regards

Dear Dr. Fazleh Mahomed ,

Identifying the natural sources of Coenzyme Q10 will do a lot of good. See this BBC News:

1. https://www.bbc.com/news/stories-45971416

2. https://www.bbc.com/news/health-45992725

Natural Sources of Coenzyme Q10

https://www.healthline.com/nutrition/coenzyme-q10#section12

Food Sources of CoQ10

While you can easily consume CoQ10 as a supplement, it can also be found in some foods.

It appears that CoQ10 is similarly absorbed in capsule form or through foods (67).

The following foods contain CoQ10:

• Organ meats: Heart, liver and kidney
• Some muscle meats: Pork, beef and chicken
• Fatty fish: Trout, herring, mackerel and sardine
• Vegetables: Spinach, cauliflower and broccoli
• Fruit: Oranges and strawberries
• Legumes: Soybeans, lentils and peanuts
• Nuts and seeds: Sesame seeds and pistachios
• Oils: Soybean and canola oil

It is clear that many chronic diseases are associated with mitochondrial dysfunction. Further, it is clear that CoQ is a key factor in the activity of mitochondrial electron transport chain. If, as it has been demonstrated, CoQ synthesis decreases during aging or is affected by inflammation and other metabolic factors, is seems that supplementation can be important to maintain or, at least, improve mitochondrial function.

Further, the importance of CoQ in plasma, associated with lipoproteins and mainly with LDL, and its function to prevent oxidation makes CoQ a very important factor to prevent atherosclerosis.

There are a lot of evidences that makes Q10 a great supplement for a variety of diseases. However, Q10 has a problem: Its low bioavailability. Only about 5% or less of Q10 is absorbed via intestine, making the optimal concentrations very hard to reach in blood. Thats why a hidrosoluble forms of Q10 with similar properties like idebenone or MitoQ could be a great choice, however, one of the main and interesting features of Q10 is its liposolubility and its capacity to stay and travel across membranes. Thats, I think, where all the controversy comes from.