Hemosiderosis occurs from iron deposition in liver resulting from multiple blood transfusions in diseases like thalassemia. Hemochromatosis results from liver iron deposition resulting from genetic [C282Y and H63D mutations of HFE gene] disturbances in iron metabolism [hepcidin, small gut iron transporters]. In aadition to liver, it also affects heart, joints, thyroid, pancreas, gonads and pituitary gland as opposed to hemosiderosis.

Dear Haematochromatosis is and iron overload disorder while haemosiderosis is iron storage disorder.

The hemochromatosis is a genetic disease of iron deposition and hemosiderosis is only a mild deposit with our genetic bases and clinical manifestations

It is a difficult definition to achieve, since people have been using it as they reckon is right for a long time now. Haemosiderosis is, technically, the deposition of haemosiderin, a pigment that may be considered normal under some circunstances. It may derive from increased haemoglobin breakdown, iatrogenic ferric overload (such as multiple blood transfusions), or other causes that increase the amount of haemosiderin present in the body. Haemochromatosis is generally used for a systemic disease, with a known cause and pathogenic process, that causes deposition of iron in multiple forms (including haemosiderin itself) in target organs. The most famous form of haemochromatosis is hereditary haemochromatosis type I, caused by bi-allelic HFE mutations, but remember there are other forms of hereditary haemochromatosis (types II, III, etc), each caused by a different mutated gene, and even acquired causes of haemochromatosis.

Chapter Hemosiderosis and Hemochromatosis

Al-Tubaikh J.A. (2010) Hemosiderosis and Hemochromatosis. In: Al-Tubaikh J.A. (eds) Internal Medicine. Springer, Berlin, Heidelberg

These are two very different conditions. There are clínically, genetically and histologíc very easy to separa one from the another

The hemocromatosis is a genetic disease and define by the clínica triad characteristic mucha as bronce skin, diabetes and cirrosis. The hemosiderosis is completeley different and dos´t have any of these clínical and genetic changes

Hemochromatosis is a rare disease in which direct deposition of iron takes place in body organs such as liver, spleen, pancreas and skin that cause tissue damage. Hemosiderosis on the other hand side is a disorder characterized by deposition of excess iron within the body tissues that normally do not containing iron.

There are two different diseases with very celar-cut diferencial diagnosis

Iron deposited in hepatocytes in Haemochromatosis with the exception of TypeIV Haemochromatosis(ferroportin disease), while in Haemosidrosis iron deposited in kupffer cells.

By definition hemochromatosis is associated with liver cirrhosis and hemosiderosis is without this chronic liver disease

I agree with dr Arvind Singh

It is not rare at all - I have just found it.

"Hereditary haemochromatosis is an iron overload

disease and is the most common genetic condition

in people of European descent. Hereditary

haemochromatosis type 1 is predominantly attributable

to two HFE gene mutations, with 95% of affected

people having the p.C282Y (p.Cyst282Tyr) mutation

and 4% having the p.C282Y/p.Hist63Asp compound

heterozygote genotype."

"The p.C282Y variant is present in 10-15% of

populations of northern European descent, with

approximately 1/150 people being homozygotes3 and

the highest genotype prevalence reported in Ireland and

Britain."

Common conditions associated with hereditary

haemochromatosis

genetic variants: cohort study in UK Biobank

Luke C Pilling,1 Jone Tamosauskaite,1 Garan Jones,1 Andrew R Wood,2 Lindsay Jones,1

Chai-

Ling Kuo,3 George A Kuchel,4 Luigi Ferrucci,5 David Melzer1,4

Cite this as: BMJ 2019;364:k5222

http://dx.doi.org/10.1136/bmj.k5222

Pigmentary Disorders

Mauricio Mota De Avelar Alchorne, Marilda Aparecida Milanez Morgado De Abreu, in Tropical Dermatology (Second Edition), 2017

Hemosiderosis and Hemochromatosis.

"The accumulation of hemosiderin in tissues with no morphologic changes causes hemosiderosis, which may be local (hemorrhage or long-lasting hyperemia) or systemic (hemolytic anemia and blood transfusion), impregnating several organs and causing brownish skin coloring. It does not require treatment. The accumulation of hemosiderin in tissues associated with functional alterations is called hemochromatosis. This could be primary (hereditary), or caused by a metabolic iron dysfunction, or secondary (excessive iron ingestion or blood transfusions) causing systemic alterations and grayish skin hyperpigmentation, which is usually generalized and more pronounced in sunlight exposed areas, thus demonstrating the involvement of melanin."

https://www.sciencedirect.com/topics/biochemistry-genetics-and-molecular-biology/hemosiderosis

There are great differences between both. In summary, Haemosiderosis is a mild disease and has a better prognosis.