Calcium is essential for many patients
why as we found that daily supplementation with 500 mg calcium citrate and 700 IU vitamin D3 for 3 years prevented increases in plasma glucose and insulin resistance in the subgroup of participants with IFG at baseline but had no apparent effect among those with NFG. There was no effect of supplementation on markers of systemic inflammation among either subgroup.
Our results are consistent with cross-sectional studies that have reported an inverse association between calcium and vitamin D status, as measured by serum 25-hydroxyvitamin D concentration and calcium intake, respectively, and prevalence of type 2 diabetes (5–11). Consumption of dairy products, a rich source of both calcium and vitamin D, has also been associated with decreased risk of type 2 diabetes (38,39). Our findings are also in accord with recently reported findings from the Nurses’ Health Study, in which a reported daily intake of >800 IU vitamin D and >1,200 mg calcium was associated with a 33% lower risk of type 2 diabetes as compared with a daily intake of
Dear Tareq Alasadi
As you see many clinical trials ongoing or were completed in relation to vitamin D and calcium supplementation in diabetes. However In newest Standards of Medical Care in Diabetes—2019 much more attention is devoted for vitamin D.
Standards of Medical Care in Diabetes—2019
http://care.diabetesjournals.org/content/42/Supplement_1
full version
http://care.diabetesjournals.org/content/diacare/suppl/2018/12/17/42.Supplement_1.DC1/DC_42_S1_Combined_FINAL.pdf
Diabetes & calcium:
https://clinicaltrials.gov/ct2/results?cond=%22diabetes%22&term=+%22calcium%22&cntry=&state=&city=&dist=&Search=Search
Diabetes & vitamin D:
https://clinicaltrials.gov/ct2/results?cond=%22diabetes%22&term=%22vitamin+D%22&cntry=&state=&city=&dist=&Search=Search
Best regards
Tomasz
Vitamin D and calcium insufficiency may negatively influence glycemia while combined supplementation with both nutrients may be beneficial in optimizing glucose metabolism.
@ Professor Tareq Abdhilkadhim Naser Alasadi Sir,
Kindly see the following RG links and PDF attachment for insights.
Article Calcium homeostasis in diabetes mellitus
Article Serum Calcium Changes and Risk of Type 2 Diabetes Mellitus i...
Thanks!
An increase in serum calcium concentrations is associated with an increased risk of type 2 diabetes.
Article Increased Serum Calcium Levels and Risk of Type 2 Diabetes i...
Article Serum Calcium Changes and Risk of Type 2 Diabetes Mellitus i...
Article Serum calcium and incident type 2 diabetes: The Atherosclero...
Interested topics, calcium enhance insulin secretion. Since for the insulin secretion needs influx of calcium, which activate proteases that converts proinsulin to active-insulin and c-peptides, moreover enhance the exocytosis of active insulin and c-peptide. But for increasing blood glucose it needs more studies to investigate the mechanism of how calcium increase both insulin and blood glucose causing insulin resistance
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5639077/
see this article please
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