When a life scientist is willing to know the functional role of a given gene product, he/she usually consults the Gene Ontology (GO) database to retrieve functional annotations associated with his/her RNA or protein of interest. But what life scientists should proceed if they want to retrieve functional annotations associated with his/her protein-protein interactions of interest, i.e. annotations considering the interaction, not the individual interacting partners
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Hi Dr. Acencio,
You can check out string database. Its a curated database from which you can know about the interacting partners and also how the each interaction is identified. The articles showing their interaction in the particular process can be obtained from here.
I hope this is what you have been looking for.
Good luck
Hello Keerthic!
Thank you for the info. I am aware of String. But I'd like to know if there is something similar to "Gene Ontology" database, but for interactions, not individual gene products.
Best,
Marcio
You can use konnect2prot.
It is a database where you can search protein(s), and construct a causal PPI network. You can also extract gene ontological information from here. What makes this website more interesting is its ability to construct localisation, biological processes, and molecular function specific subnetwork.
Hello Dipanka!
I've taken just a rapid look at the konnect2prot and it seems very promising! I will come back to you when I have finished a deeper exploration of your resource!
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