Researchers identified the human immunodeficiency virus (HIV) as the cause of acquired immune deficiency syndrome (AIDS) two decades ago. Since then, the search for an effective vaccine to the deadly infection has received more funding than any other vaccine effort in history. And the search, employing ever more innovative strategies, continues. Skeptics say no vaccine will ever be found.
HIV virus was discovered three decades ago in 1983 ;)))), time travels fast. We have no other option but to continue to develop an HIV vaccine no matter how long it takes. Likely, mucosal vaccine strategies will be most effective in prevention of HIV-1 infection.
We have all learned so much from studying HIV vaccine strategies available today and we may be closer than ever to a vaccine, if you consider the limited but significant protection from HIV acquisition obtained from the Thai human Trial (ALVAC-ge/gp120 proteins Clade E and B/ Alum strategy) in 2008/9. Now for the first time, we have a strategy that partially works in humans. We can start from there to find correlates of protection from HIV, and then to improve the efficacy of this vaccine or generate a new one based on the findings.
Scripps institute has received a 7 year, $77 million grant to develop their vaccine (see publications). Their 3 D model shows carbohydrates covering moieties which would be vaccine sites. I don't know if they can overcome this problem.
Attempts at auto-vaccination have failed using ECP in HIV infected even though the techniques is successful in CTCL and possibly GvsH disease.
On the other hand, blockade of IDO seems promising and if a vaccine strategy can target immune function and viral entry at the macrophage/DC level a functional cure or an absolute prevention could be possible.
It was actually 3 decades ago, 1983, in America the virus was known as HTLV III and in France as LAV, the respective labs of Robert Gallo Luc Montagnier. I will never forget those days. I no longer work in the science at all but I came to believe back than and still do that no TRADITIONAL vaccine, as in a one size fits all prep that is given to all to confer immunity from a later challenge will ever be possible. Something along the lines of a cellular vaccine maybe.
The focus is now on working on latent virii. To target the virus hiding in reservoirs like gamma delta CD-4 cells in the GI tract. The problem is to find a suitable drug which can target these sites and other similar sites or to flush the virus out these revoirs when the active drugs can work. Lot of dat have been prented recently in Atalanta CROI meeting.
Hi Friend Thanks for your answers,
Please may i know the list of vaccine name for HIV. Among, which is very cheap and available in market.
Unfortunately, There is no any Vaccine available in market. Some of the vaccines are under clinical trial... Hope for the best..
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