J Inorg Biochem. 2005 Sep;99(9):1895-8.

Nanomolar aluminum induces pro-inflammatory and pro-apoptotic gene expression in human brain cells in primary culture.

Lukiw WJ, Percy ME, Kruck TP.

Source

Neuroscience Center of Excellence and Department of Ophthalmology, Louisiana State University Health Sciences Center, 2020 Gravier Street, Suite 8B8, New Orleans, LA 70112-2272, USA. [email protected]

Abstract

Aluminum, the most abundant neurotoxic metal in our biosphere, has been implicated in the etiology of several neurodegenerative disorders including Alzheimer's disease (AD). To further understand aluminum's influence on gene expression, we examined total messenger RNA levels in untransformed human neural cells exposed to 100 nanomolar aluminum sulfate using high density DNA microarrays that interrogate the expression of every human gene. Preliminary data indicate that of the most altered gene expression levels, 17/24 (70.8%) of aluminum-affected genes, and 7/8 (87.5%) of aluminum-induced genes exhibit expression patterns similar to those observed in AD. The seven genes found to be significantly up-regulated by aluminum encode pro-inflammatory or pro-apoptotic signaling elements, including NF-kappaB subunits, interleukin-1beta precursor, cytosolic phospholipase A2, cyclooxygenase-2, beta-amyloid precursor protein and DAXX, a regulatory protein known to induce apoptosis and repress transcription. The promoters of genes up-regulated by aluminum are enriched in binding sites for the stress-inducible transcription factors HIF-1 and NF-kappaB, suggesting a role for aluminum, HIF-1 and NF-kappaB in driving atypical, pro-inflammatory and pro-apoptotic gene expression. The effect of aluminum on specific stress-related gene expression patterns in human brain cells clearly warrant further investigation.

@Joseph - Don't forget about the fluoride in tea! Bon Appetite!

@ Joseph - When you analyze the VAERS database comparing the incidence of reports of death in Al-containing vaccines against vaccines w/out Al, it becomes clear that all of the commercially-marketed Al containing vaccines have greater numbers of reports of death, sometimes sudden death. HPV vaccine is a case in point. Serendipity? Of course, association does not establish causality, but have you wondered why metallomics studies are showing high Al levels in samples from autism patients? More serendipity? Also, if causality between Al and sudden death was ever firmly established, that would make the century of Al-related deaths in substantial measure iatrogenic, yes? Our environmental exposure to neurotoxicants is ever increasing. Al is in the food supply, cosmetics, sunblocks, etc. It's also in upper outer quadrant breast cancers. More serendipity?

Dear Robert

In contact with the body these metals end up attracting to itself essential elements of the body such as proteins and enzymes. Eventually they join some of them, preventing work, and may join the cell walls hindering the transport of nutrients and can cause the death

Lead, mercury, aluminum, fluoride and other heavy metals are considered as one of the causes of Alzheimer's disease. Heavy metals enter the body through several ways, but primarily through: dental amalgam (mercury), cooking utensils (aluminum, iron), food and beverages (aluminum mercury) polluted air (lead and many others)

If lead was the cause for Alziehmers then half of indian Polpulation would end up with this disease. Aluminum has become a part of our life begening with the new born.