Does it affect the reaction if the cis-isomeric form of PdCl2(PPh3)2 is used as catalyst in the Sonogashira Coupling?
Because if we use cis-form then there won't be any requirement of cis/trans isomerization after transmetalation in the Sonogashira !
Dear Saurav Raj thank you for this interesting question. Please see this useful Wikipedia entry on
Bis(triphenylphosphine)palladium chloride
https://en.wikipedia.org/wiki/Bis(triphenylphosphine)palladium_chloride
In this article it is stated that "Several crystal structures containing PdCl2(PPh3)2 have been reported. In all of the structures, PdCl2(PPh3)2 adopts a square planar coordination geometry and the trans isomeric form."
Dear Saurav Raj one more information: When you want to buy the complex bis(triphenylphosphine)palladium chloride from commercially suppliers you will find that they offer only the trans isomeric form:
https://www.sigmaaldrich.com/catalog/product/aldrich/412740?lang=de®ion=DE
Dear Frank T. Edelmann thank you for your answer, and sharing the information regarding the purchase of the chemicals
You may try both of them. But the difference seems to be small from the normal mechanism.
- Badges
- Science topic
- Similar topics
- Instrumentation Engineering
- Instruments