Sorry Raheem your question does not make sense for me:

RNase treatment of Exosomes is necessary to remove cellular RNAs trapped outside the exosomes when you are looking for intra-exosome RNAs.  Rnase A or H do not have proteases activity, they can only confuse your exosome protein profile .  

Dear Paola. Thank you for responses and answer. However, it is not completely clear for me. I would to use RNase A to inhibit exosomes RNA, but the question is how can improve that RNase A get inside the exosomes? For example the exosomes membrane could prevent RNase A to get inside the exosomes. Secondly if I use proteinase  k that could denaturation exosomel protein.

Dear Raheem. I don´t know if i understood you correctly. Do you want to remove RNAs from outside exosomes or do you want to "empty" the RNA content of exosomes? For the first option you can just try several concentrations of RNAses to check what´s the optimal for your sample. The second option is more complicated. You will break the exosome in order to remove "all" the nucleic acid content, damaging their structure and probably affecting the functionality. Why don´t you try creating, for instance, artificial nanovesicles instead or liposomes with the lipid composition of exosomes?